Kw. Marvin et al., Intercellular adhesion molecule-1 (ICAM-1) in cervicovaginal fluid of women presenting with preterm labor: Predictive value for preterm delivery, AM J REPROD, 43(5), 2000, pp. 264-271
PROBLEM: Clinically useful tests for the prediction and diagnosis of preter
m labor and delivery remain to be established. We have hypothesized that so
luble intercellular adhesion molecule-1 (sICAM-1) in the cervicovaginal flu
id of women with preterm labor may be a useful diagnostic tool.
METHOD OF STUDY: The cervicovaginal fluid of 103 women between 24 degrees a
nd 33(6) weeks gestation with preterm contractions and intact membranes was
assayed for sICAM-1.
RESULTS: Elevated sICAM-1 concentrations predicted short intervals to deliv
ery (area under receiver-operator characteristic (ROC) curves, 0.70-0.72 fo
r delivery within 3, 7 and 10 days), with high specificity. Characteristics
for delivery within 3 days at a 3 ng/mL threshold for a positive test were
sensitivity 33.3%, specificity 98.9% and positive and negative predictive
values of 75.0% and 93.9%, respectively. Predictive ability was independent
of and complementary to that of fetal fibronectin (fFN).
CONCLUSIONS: Measurement of sICAM-1 in cervicovaginal fluid has potential a
s a predictor of preterm delivery in women with symptoms of preterm labor,
particularly in conjunction with fFN testing.