Intracavitary urokinase for enhancement of percutaneous abscess drainage: Phase II trial

OBJECTIVE. To evaluate the effectiveness of urokinase as an abscess-cavity irrigant during percutaneous abscess drainage. SUBJECTS AND METHODS. In a prospective study, approved by the Food and Drug Administration and the review board at our institution, urokinase and sali ne were used as abscess-cavity irrigants. In the study group of 42 patients , half the patients were randomly placed into the urokinase group and the o ther half were placed into the control saline group. Doses used varied with the size of the abscess. Data collected from patient charts were evaluated with standard statistical methods. RESULTS. The results indicate definite benefits of the urokinase treatment. The length of stay (p = 0.0025) and treatment costs (p = 0.0021) were sign ificantly less for the urokinase group. Other clinical parameters, includin g the febrile course, elevated WBC, and days of drainage, trended in a favo rable fashion. CONCLUSION. Urokinase injected intracavitarily is an effective technique fo r shortening the treatment time and improves the clinical course for patien ts treated with percutaneous drainage techniques.