Citation
Yz. Xian et al., Direct measurement of nitric oxide release from the rat hippocampus, ANALYT CHIM, 415(1-2), 2000, pp. 127-133
Citations number
49
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICA CHIMICA ACTA
ISSN journal
00032670
→ ACNP
Volume
415
Issue
1-2
Year of publication
2000
Pages
127 - 133
Database
ISI
SICI code
0003-2670(20000630)415:1-2<127:DMONOR>2.0.ZU;2-9
Abstract
A novel, sensitive, selective and reproducible nitric oxide (NO) microsenso
r is developed for direct measurement of NO in vitro and in vivo. Using the
microsensor, the first direct measurements NO release from the rat hippoca
mpus are made. NO levels are increased by stimulated with L-arginine and ac
etylcholine. L-N-omega-nitro-arginine, a NO synthase inhibitor, decreases t
he NO increase induced by L-arginine and acetylcholine. The effect of sodiu
m nitroprusside, a NO donor, is also performed. (C) 2000 Elsevier Science B
.V. All rights reserved.