Extractive spectrophotometric determination of chlorprothixene hydrochloride

A simple, rapid and accurate method for determination of chlorprothixene hy drochloride is presented. It is based on the liability of the chlorprothixe ne ternary amine group nitrogen atom to form ion pair complexes with niobiu m (V) thiocyanate complex. The formed compound is insoluble in water but we ll soluble in some organic solvents. The reaction is followed spectrophotom etrically by measuring the absorbance at lambda= 362 nm. This property has been successfully used for the extractive spectrophotometric determination of chlorprothixene. Beer's law was obeyed in the range 9- 50 mu g/ mi of ch lorprothixene hydrochloride. The method is suitable to the determination of analyte in commercial products. The results were compared with those obtai ned by the official procedure.