Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin

Authors
Peteroy, M Severin, A Zhao, F Rosner, D Lopatin, U Scherman, H Belanger, A Harvey, B Hatfull, GF Brennan, PJ Connell, ND
Citation
M. Peteroy et al., Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin, ANTIM AG CH, 44(6), 2000, pp. 1701-1704
Citations number
17
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
6
Year of publication
2000
Pages
1701 - 1704
Database
ISI
SICI code
0066-4804(200006)44:6<1701:COAMSM>2.0.ZU;2-L
Abstract
A mutant of Mycobacterium smegmatis has been isolated that is simultaneousl y resistant to both D-cycloserine ((D)-CS) and vancomycin. Genetic compleme ntation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechani sm involving peptidoglycan assembly at the cell surface.