Antileishmanial activities of stearylamine-bearing liposomes

Authors
Dey, T Anam, K Afrin, F Ali, N
Citation
T. Dey et al., Antileishmanial activities of stearylamine-bearing liposomes, ANTIM AG CH, 44(6), 2000, pp. 1739-1742
Citations number
23
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
6
Year of publication
2000
Pages
1739 - 1742
Database
ISI
SICI code
0066-4804(200006)44:6<1739:AAOSL>2.0.ZU;2-E
Abstract
Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA) against Leishmania donovani parasites. Both pro mastigotes and intracellular amastigotes in vitro and in vivo were suscepti ble to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes/animal co uld significantly reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral leishmaniasis, respectively, s uggesting their strong therapeutic potential.