Single-oral-dose azithromycin prophylaxis against experimental streptococcal or staphylococcal aortic valve endocarditis

Authors
Tsitsika, A Pefanis, A Perdikaris, GS Donta, I Karayiannakos, P Giamarellou, H
Citation
A. Tsitsika et al., Single-oral-dose azithromycin prophylaxis against experimental streptococcal or staphylococcal aortic valve endocarditis, ANTIM AG CH, 44(6), 2000, pp. 1754-1756
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
6
Year of publication
2000
Pages
1754 - 1756
Database
ISI
SICI code
0066-4804(200006)44:6<1754:SAPAES>2.0.ZU;2-9
Abstract
Azithromycin and ampicillin protected 94 and 72% of animals challenged with Streptococcus oralis, respectively (P = 0.177), while azithromycin and van comycin protected 59 and 94% of the methicillin -resistant Staphylococcus a ureus (MRSAchallenged animals,respectively (P=0.018). Azithromycin is effec tive in preventing experimental streptococcal endocarditis, but against MRS A it is less effective than vancomycin.