Postantibiotic suppression of growth of erythromycin A-susceptible and -resistant gram-positive bacteria by the ketolides telithromycin (HMR 3647) and HMR 3004

Authors
Munckhof, WJ Borlace, G Turnidge, JD
Citation
Wj. Munckhof et al., Postantibiotic suppression of growth of erythromycin A-susceptible and -resistant gram-positive bacteria by the ketolides telithromycin (HMR 3647) and HMR 3004, ANTIM AG CH, 44(6), 2000, pp. 1749-1753
Citations number
17
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
6
Year of publication
2000
Pages
1749 - 1753
Database
ISI
SICI code
0066-4804(200006)44:6<1749:PSOGOE>2.0.ZU;2-8
Abstract
We investigated the in vitro postantibiotic effects (PAEs) of the ketolides telithromycin (HMR 3647) and HMR 3004 and analyzed the results using the s igmoid E-max model. Mean maximum telithromycin PAEs against erythromycin A- susceptible strains of Staphylococcus aureus, Streptococcus pyogenes, and S treptococcus pneumoniae mere 3.7, 8.9, and 9.7 h, respectively, while maxim um PAEs for erythromycin A-resistant strains were much shorter, Mean maximu m HMR 3004 PAEs were 3.2 to 4.4 h for all species.