A CONVENIENT ROUTE TO NEW FLUORINATED PHOTODYNAMIC THERAPEUTIC PHOTOSENSITIZERS BASED ON MESO-TETRA(HYDROXYPHENYL)PORPHYRINS

Authors
SONGCA SP BONNETT R MAES CM
Citation
Sp. Songca et al., A CONVENIENT ROUTE TO NEW FLUORINATED PHOTODYNAMIC THERAPEUTIC PHOTOSENSITIZERS BASED ON MESO-TETRA(HYDROXYPHENYL)PORPHYRINS, South African Journal of Chemistry, 50(1), 1997, pp. 40-47
Citations number
24
Categorie Soggetti
Chemistry
Journal title
South African Journal of Chemistry → ACNP
ISSN journal
03794350
Volume
50
Issue
1
Year of publication
1997
Pages
40 - 47
Database
ISI
SICI code
0379-4350(1997)50:1<40:ACRTNF>2.0.ZU;2-E
Abstract
A general synthetic route was developed for the synthesis of new fluor inated tetra(hydroxyphenyl) porphyrins ,15,20-tetrakis(2-fluoro-3-hydr oxyphenyl)porphyrin 10, 20-tetrakis(2,4-difluoro-3-hydroxyphenyl)porph yrin 11, and 20-tetrakis(3,5-difluoro-4-hydroxyphenyl)porphyrin 12], a nalogues of sensitisers 1-3 which are known to be active in vivo in ca ncer photodynamic therapy.