Citation
T. Shinozaki et al., Human leukocyte antigen (HLA) phenotypes in siblings with osteosarcoma, ARCH ORTHOP, 120(5-6), 2000, pp. 343-345
Citations number
17
Categorie Soggetti
Ortopedics, Rehabilitation & Sport Medicine
Journal title
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
ISSN journal
09368051
→ ACNP
Volume
120
Issue
5-6
Year of publication
2000
Pages
343 - 345
Database
ISI
SICI code
0936-8051(200004)120:5-6<343:HLA(PI>2.0.ZU;2-3
Abstract
Osteosarcoma was detected in two siblings. Their human leukocyte antigen (H
LA) phenotypes were completely identical, although they were different from
those of osteosarcoma patients in previous reports. Despite an extensive s
earch of family and past history, no significant background related to the
induction of cancer could be found. These cases suggest that genetic simila
rity may influence the development of osteosarcoma. Ascertainment of the HL
A phenotypes in siblings with osteosarcoma might be a useful strategy to fa
cilitate the early diagnosis of this tumor.