Growth hormone receptor antagonists therapy for acromegaly

Authors
Parkinson, C Trainer, PJ
Citation
C. Parkinson et Pj. Trainer, Growth hormone receptor antagonists therapy for acromegaly, BEST PRAC R, 13(3), 1999, pp. 419-430
Citations number
68
Categorie Soggetti
Endocrynology, Metabolism & Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
ISSN journal
1521690X → ACNP
Volume
13
Issue
3
Year of publication
1999
Pages
419 - 430
Database
ISI
SICI code
1521-690X(199910)13:3<419:GHRATF>2.0.ZU;2-T
Abstract
Knowledge of the interaction between growth hormone (GH) and the growth hor mone receptor (GHR) has led to the rational design of a GHR antagonist. An analogue of GH able to block the action of GH at the cellular level offers greater specificity of effect compared with current medical therapies and i s not dependent on tumour characteristics. This chapter reviews the interac tion between GH and the GHR, and discusses the outstanding issues regarding GHR antagonist therapy in acromegaly.