T. Fujiwara et al., Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2, BIOC BIOP R, 271(3), 2000, pp. 626-629
Citations number
35
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
mDial is a downstream effector of Rho small G: protein that is implicated i
n stress fiber formation and cytokinesis. We isolated an mDial-binding prot
ein and identified it to be IRSp53/BAIAP2. IRSp53 and BAIAP2 have independe
ntly been isolated as a 58/53-kDa protein tyrosine phosphorylated in respon
se to insulin and a BAI1-binding protein, respectively. BAI1 is a brain-spe
cific seven-span transmembrane protein capable of inhibiting angiogenesis.
The proline-rich formin homology 1 domain of mDial bound the Src homology 3
domain of IRSp53/BAIAP2 in a GTP-Rho-dependent manner. The results suggest
that IRSp53/BAIAP2 is a downstream effector of mDial. (C) 2000 Academic Pr
ess.