SAR studies of 2-o-substituted-benzoyl- and 2-alkanoylcyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase

Authors
Lin, YL Wu, CS Lin, SW Yang, DY
Citation
Yl. Lin et al., SAR studies of 2-o-substituted-benzoyl- and 2-alkanoylcyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase, BIOORG MED, 10(9), 2000, pp. 843-845
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
9
Year of publication
2000
Pages
843 - 845
Database
ISI
SICI code
0960-894X(20000501)10:9<843:SSO2A2>2.0.ZU;2-0
Abstract
Inhibition studies of 4-hydroxyphenylpyruvate dioxygenase (HPPD) with vario us synthesized 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-dion es suggest that the presence of a strongly electronegative group at the ort ho position and the conformation of the benzene ring moiety on the benzoylc yclohexane-1,3-dione inhibitors are crucial for potent HPPD inhibition. (C) 2000 Elsevier Science Ltd. All rights reserved.