Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-alpha suppression and IL-10 augmentation

Authors
Hanano, T Adachi, K Aoki, Y Morimoto, H Naka, Y Hisadome, M Fukuda, T Sumichika, H
Citation
T. Hanano et al., Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-alpha suppression and IL-10 augmentation, BIOORG MED, 10(9), 2000, pp. 881-884
Citations number
6
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
9
Year of publication
2000
Pages
881 - 884
Database
ISI
SICI code
0960-894X(20000501)10:9<881:NDOTBO>2.0.ZU;2-3
Abstract
A series of arylpiperazine derivatives was synthesized to obtain agents sho wing apparent therapeutic effects in a chronic inflammatory animal model, s tarting from a lead possessing potent dual cytokine regulatory activity in vivo. We found a pyrimidylpiperazine derivative 17c showing the dual regula tory activity and an excellent therapeutic effect in an adjuvant-induced ar thritis model. (C) 2000 Elsevier Science Ltd. All rights reserved.