5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: Potential treatments for migraine

Authors
Meng, CQ Rakhit, S Lee, DKH Kambo, R McCallum, KL Mazzocco, L Dyne, K Slassi, A
Citation
Cq. Meng et al., 5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: Potential treatments for migraine, BIOORG MED, 10(9), 2000, pp. 903-905
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
9
Year of publication
2000
Pages
903 - 905
Database
ISI
SICI code
0960-894X(20000501)10:9<903:5DAS5R>2.0.ZU;2-J
Abstract
A series of 5-(2- or 3-thienyl)tryptamine derivatives (9) has been synthesi zed and shown to be potent and selective 5-HT1D versus 5-HT1B receptor agon ists and, therefore, potential treatments for migraine. (C) 2000 Elsevier S cience Ltd. All rights reserved.