Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: Potential therapeutic applications for epilepsy and obesity

Authors
Isaac, M Slassi, A O'Brien, A Edwards, L MacLean, N Bueschkens, D Lee, DKH McCallum, K De Lannoy, I Demchyshyn, L Kamboj, R
Citation
M. Isaac et al., Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: Potential therapeutic applications for epilepsy and obesity, BIOORG MED, 10(9), 2000, pp. 919-921
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
9
Year of publication
2000
Pages
919 - 921
Database
ISI
SICI code
0960-894X(20000501)10:9<919:PDA5RA>2.0.ZU;2-E
Abstract
A series of pyrrolo[3,2,1-ij]quinoline derivatives was synthesized, evaluat ed for their activity against the 5-HT2c and 5-HT2a, receptors and found to be agonists at 5-HT2c with selectivity over 5-HT2a. (C) 2000 Elsevier Scie nce Ltd. All rights reserved.