Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: Potent inhibitors of the tyrosine kinase c-Src

Authors
Missbach, M Altmann, E Widler, L Susa, M Buchdunger, E Mett, H Meyer, T Green, J
Citation
M. Missbach et al., Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: Potent inhibitors of the tyrosine kinase c-Src, BIOORG MED, 10(9), 2000, pp. 945-949
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
9
Year of publication
2000
Pages
945 - 949
Database
ISI
SICI code
0960-894X(20000501)10:9<945:S5PIOT>2.0.ZU;2-X
Abstract
5,7-Diphenyl-pyrrolol[2,3d]pyrimidines represent a new class of highly pote nt inhibitors of the tyrosine kinase c-Src (IC50 < 50 nM) with specificity against a panel of different tyrosine kinases. The substitution pattern on the two phenyl rings determines potency and specificity and provides a mean s to modulate cellular activity. (C) 2000 Elsevier Science Ltd. All rights reserved.