Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors

Authors
Tamura, SY Weinhouse, MI Roberts, CA Goldman, EA Masukawa, K Anderson, SM Cohen, CR Bradbury, AE Bernardino, VT Dixon, SA Ma, MG Nolan, TG Brunck, TK
Citation
Sy. Tamura et al., Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors, BIOORG MED, 10(9), 2000, pp. 983-987
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
9
Year of publication
2000
Pages
983 - 987
Database
ISI
SICI code
0960-894X(20000501)10:9<983:SABAOP>2.0.ZU;2-L
Abstract
Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokina se-type plasminogen activator based on the sequence dSerAlaArg-al are descr ibed. The biological activities of these unique inhibitors are reported her ein. Carbonate prodrugs were prepared and tested as potential drug delivery systems. (C) 2000 Published by Elsevier Science Ltd.