Discovery and evaluation of potent, tyrosine-based alpha 4 beta 1 integrinantagonists

Authors
Archibald, SC Head, JC Gozzard, N Howat, DW Parton, TAH Porter, JR Robinson, MK Shock, A Warrellow, GJ Abraham, WM
Citation
Sc. Archibald et al., Discovery and evaluation of potent, tyrosine-based alpha 4 beta 1 integrinantagonists, BIOORG MED, 10(9), 2000, pp. 997-999
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
9
Year of publication
2000
Pages
997 - 999
Database
ISI
SICI code
0960-894X(20000501)10:9<997:DAEOPT>2.0.ZU;2-8
Abstract
Using disulphide cysteine-based inhibitors as lead structures, this communi cation describes our strategy for identifying more stable, potent antagonis ts of the alpha 4 beta 1 integrin. These studies ultimately discovered pote nt, low molecular weight inhibitors based on D-thioproline-L-tyrosine. (C) 2000 Elsevier Science Ltd. All rights reserved.