Anti-AIDS agents part 41: Synthesis and anti-HIV activity of 3 ',4 '-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues

Authors
Yang, ZY Xia, Y Xia, P Brossi, A Cosentino, LM Lee, KH
Citation
Zy. Yang et al., Anti-AIDS agents part 41: Synthesis and anti-HIV activity of 3 ',4 '-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues, BIOORG MED, 10(10), 2000, pp. 1003-1005
Citations number
6
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
10
Year of publication
2000
Pages
1003 - 1005
Database
ISI
SICI code
0960-894X(20000515)10:10<1003:AAP4SA>2.0.ZU;2-X
Abstract
DCK lactam analogues were synthesized and evaluated for anti-HIV activity a gainst HIV-1 replication in H9 lymphocyte cells. 4-Methyl-DCK lactam (11a) exhibited potent anti-HIV activity with EC50 and therapeutic index values o f 0.00024 mu M and 119,333, respectively. (C) 2000 Elsevier Science Ltd. Al l rights reserved.