Antimycobacterial activity of ionic fullerene derivatives

Authors
Bosi, S Da Ros, T Castellano, S Banfi, E Prato, M
Citation
S. Bosi et al., Antimycobacterial activity of ionic fullerene derivatives, BIOORG MED, 10(10), 2000, pp. 1043-1045
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
10
Year of publication
2000
Pages
1043 - 1045
Database
ISI
SICI code
0960-894X(20000515)10:10<1043:AAOIFD>2.0.ZU;2-L
Abstract
Positively charged fullerene derivatives, moderately soluble in water:DMSO 9:1, have been tested using three strains of Mycobacterium spp. Some compou nds inhibit the growth of Mycobacterium tubercolosis, a human clinical isol ate, particularly virulent and resistant, at doses as low as 5 mu g/mL. (C) 2000 Elsevier Science Ltd. All rights reserved.