Yj. Zheng et al., Synthesis and structural analysis of the active enantiomer of famoxadone, a potent inhibitor of cytochrome bc(1), BIOORG MED, 10(10), 2000, pp. 1059-1062
Famoxadone is a newly commercialized fungicide and potent Q(o)-site inhibit
or of cytochrome bet. The S-(-)-enantiomer of famoxadone (the active compon
ent) was synthesized by two routes and was analyzed computationally and by
X-ray crystallography. The molecule displays an extended conformation with
flexibility in the structure imparted by the two terminal phenyl groups. In
the crystal lattice, intermolecular hydrogen bonds occur between the NH an
d the oxygen atoms of the heterocycle. (C) 2000 Elsevier Science Ltd. All r
ights reserved.