Examination of N-hydroxylation as a prerequisite mechanism of nitric oxidesynthase inactivation

Authors
Maurer, TS Pan, JP Booth, BP Kalman, TI Fung, HL
Citation
Ts. Maurer et al., Examination of N-hydroxylation as a prerequisite mechanism of nitric oxidesynthase inactivation, BIOORG MED, 10(10), 2000, pp. 1077-1080
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
10
Year of publication
2000
Pages
1077 - 1080
Database
ISI
SICI code
0960-894X(20000515)10:10<1077:EONAAP>2.0.ZU;2-U
Abstract
L-N-5-(1-Hydroxyiminoethyl)-ornithine (L-NHIO) and L-N-6-(1-hydroxyiminoeth yl)-lysine (L-NHIL) were synthesized and tested as potential intermediates in the mechanism-based inactivation of nitric oxide synthase (NOS) by L-N-5 -iminoethylornithine (L-NIO) and L-N-6-iminoethyllysine (L-NIL). Although t hese compounds were determined to be competitive inhibitors, mechanism-base d inactivation was not observed. (C) 2000 Elsevier Science Ltd. All rights reserved.