First pharmacophoric hypothesis for 5-HT7 antagonism

Authors
Lopez-Rodriguez, ML Porras, E Benhamu, B Ramos, JA Morcillo, MJ Lavandera, JL
Citation
Ml. Lopez-rodriguez et al., First pharmacophoric hypothesis for 5-HT7 antagonism, BIOORG MED, 10(10), 2000, pp. 1097-1100
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
10
Year of publication
2000
Pages
1097 - 1100
Database
ISI
SICI code
0960-894X(20000515)10:10<1097:FPHF5A>2.0.ZU;2-O
Abstract
In order to make the first contribution to the elucidation of essential str uctural features for 5-HT7 antagonism, a set of thirty 5-HT7 antagonists we re selected from the literature. A pharmacophore model was built using Mole cular Modeling studies with Catalyst program, The information contained in this model was validated with new synthesized compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.