Syntheses and properties of photoactivatable sugar derivatives designed toprobe the sugar-binding site of melibiose permease

Authors
Ambroise, Y Mioskowski, C Leblanc, G Rousseau, B
Citation
Y. Ambroise et al., Syntheses and properties of photoactivatable sugar derivatives designed toprobe the sugar-binding site of melibiose permease, BIOORG MED, 10(10), 2000, pp. 1125-1127
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
10
Year of publication
2000
Pages
1125 - 1127
Database
ISI
SICI code
0960-894X(20000515)10:10<1125:SAPOPS>2.0.ZU;2-6
Abstract
Three new photoreactive sugar analogues bearing an azido, a diazonium salt or a diazirine group as the photophore as well as a tritium atom were devel oped. Two of these new photoactivatable compounds gave excellent preliminar y results, with a high affinity for the melibiose permease of Escherichia c oli. (C) 2000 Elsevier Science Ltd. All rights reserved.