Extraction of tylosin from its aqueous solutions by Rotating Film-pertraction

Removal of tylosin from its dilute aqueous solutions was studied applying t he Rotating Film-pertraction technique. Non-toxic and practically water ins oluble alcohols as n-octanol and iz-decanol were used as intermediate, memb rane liquid. A 0.001 mol/l solution of HCl was used as a stripping phase. E ffects of temperature, feed phase pH-value and solute concentration on anti biotic distribution coefficients were obtained for both systems. it was fou nd that the first two parameters have important effect, while the solute co ncentration in the studied range (0.02-0.1 g/l) did not modify these coeffi cients. Results obtained show that the first pertraction step - solute extr action from the feed - is a very fast process, while the second one - the a lcohol stripping - is relatively slow, in particular when octanol was used as membrane phase. A mathematical model was proposed and used for evaluatio n of corresponding local mass transfer coefficients.