Phototherapy with blue (415 nm) and red (660 nm) light in the treatment ofacne vulgaris

In this study we have evaluated the use of blue light (peak at 415 nm) and a mixed blue and red light (peaks at 415 and 660 nm) in the treatment of ac ne vulgaris, One hundred and seven patients with mild to moderate acne vulg aris were randomized into four treatment groups: blue light, mixed blue and red light, cool white light and 5% benzoyl peroxide cream, Subjects in the phototherapy groups used portable light sources and irradiation was carrie d out daily for 15 min. Comparative assessment between the three light sour ces was made in an observer-blinded fashion, but this could not be achieved for the use of benzoyl peroxide, Assessments were performed every 4 weeks, After 12 weeks of active treatment a mean improvement of 76% (95% confiden ce interval 66-87) in inflammatory lesions was achieved by the combined blu e-red light phototherapy; this was significantly superior to that achieved by blue light (at weeks 4 and 8 but not week 12), benzoyl peroxide (at week s 8 and 12) or white light (at each assessment). The final mean improvement in comedones by using blue-red light was 58% (95% confidence interval 45-7 1), again better than that achieved by the other active treatments used, al though the differences did not reach significant levels. We have found that phototherapy with mixed blue-red light, probably by combining antibacteria l and anti-inflammatory action, is an effective means of treating acne vulg aris of mild to moderate severity with no significant short-term adverse ef fects.