Odorant inhalation affects skin barrier homeostasis in mice and humans

Previous studies have suggested that psychological stress delays cutaneous barrier recovery following acute barrier disruption, and that sedative drug s block this delay A sedative effect of some odorants has been reported, In the present study, we demonstrate that odorant inhalation affects cutaneou s barrier homeostasis in both mice and humans. Odorants with a sedative eff ect prevented the delay of skin barrier recovery induced by stress after ac ute barrier disruption. Other odorants did not show this effect.