Clinical presentation of a group of NF2 patients to a tertiary referral skull base unit

The objective of the investigation was to document the clinical presentatio ns of a group of patients with neurofibromatosis type two syndrome (NF2), a nd took the form of a retrospective case note review. The investigation too k place in the tertiary referral skull base unit. The dominant presentation of patients with NF2 is with auditory/vestibular symptoms (56%), with a sm aller proportion of presentations being due to non-acoustic intracranial an d spinal tumours (44%). At the time of presentation the majority of clinica lly significant rumours could be demonstrated in each patient with MRI of t he head and spine, with few new rumours arising during the subsequent follo w-up period. The range of presentation of patients with NF2 results in thei r management being fragmented into a variety of clinical settings, diluting the experience amassed in any one centre.