Passerini multicomponent reaction of protected alpha-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors

Authors
Banfi, L Guanti, G Riva, R
Citation
L. Banfi et al., Passerini multicomponent reaction of protected alpha-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors, CHEM COMMUN, (11), 2000, pp. 985-986
Citations number
16
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
11
Year of publication
2000
Pages
985 - 986
Database
ISI
SICI code
1359-7345(2000):11<985:PMROPA>2.0.ZU;2-3
Abstract
Three-component Passerini condensation of N-Boc-alpha-aminoaldehydes with v arious isocyanides and carboxylic acids leads, after Boc-deprotection/trans acylation, to complex peptide-like structures containing an alpha-hydroxy-b eta-aminoacid unit or, after oxidation, an alpha-oxo-beta-aminoacid unit.