Neurodegeneration: new clues on inclusions

The rare neurological disorders frontotemporal dementia and British dementi a have been linked to two mutant genes whose products constitute the fibril s that define the two disease pathologies, Two recent studies add to the mo unting circumstantial case that protein fibrillization, inside (neurofibril lary tangles) or outside (amyloid plaques) of the neuron, may be pathogenic and suggest that either or both of these mechanisms could initiate Alzheim er's disease.