Depersonalization in panic disorder: A clinical study

Panic disorder (PD) has been hypothesized to be a heterogeneous entity, wit h distinct clinical subgroups. The presence of depersonalization during pan ic attacks may distinguish a specific subgroup of PD, We sought to analyze the differential features of a subgroup of PD patients with depersonalizati on. A total of 274 patients with PD were assessed and divided into 2 groups according to the presence or absence of depersonalization. The Structured Clinical Interview for DSM-III-R (SCID-UP-R) was used to assess PD and como rbid disorders. The clinical scales administered included the Hamilton Anxi ety and Depression Rating Scale (HARS and HDRS), the Marks and Mathews Fear s and Phobia Scale, Panic-Associated Symptom Scale (PASS), and a panic atta ck symptoms inventory. A total of 66 patients (24.1%) exhibited depersonali zation during the attacks. Patients with depersonalization appeared to be y ounger and had an earlier age at onset. PD was more severe in the depersona lization group (greater number of attacks, worse level of functioning, and higher scores on most self-rating scales). Also, depersonalization patients showed more comorbidity with specific phobia. Our results support the view that PD with depersonalization may be considered a distinct and more sever e subcategory of PD. Copyright (C) 2000 by W.B. Saunders Company.