Functions of Lsm proteins in mRNA degradation and splicing

Authors
He, WH Parker, R
Citation
Wh. He et R. Parker, Functions of Lsm proteins in mRNA degradation and splicing, CURR OP CEL, 12(3), 2000, pp. 346-350
Citations number
29
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
12
Issue
3
Year of publication
2000
Pages
346 - 350
Database
ISI
SICI code
0955-0674(200006)12:3<346:FOLPIM>2.0.ZU;2-4
Abstract
Recent results have identified a family of Lsm (Like Sm) proteins that are related to the Sm protein family. Seven Lsm proteins form a complex, which interacts with the U6 snRNA and functions in splicing. In addition. a diffe rent complex of Lsm proteins interacts with cytoplasmic mRNA and promotes i ts turnover. These diverse functions of Lsm proteins suggest that they are important modulators of RNA biogenesis and function.