Of utmost importance in the practice of neurological critical care is the t
reatment of cerebral edema, when possible, and the control of life-threaten
ing seizures. In this regard, severe traumatic head injury and refractory s
tatus epilepticus are useful clinical therapeutic paradigms. Evidence-based
treatment established for these conditions has, by necessity, a wider appl
ication to other much less frequent causes of coma and acute neurological i
llness managed in the intensive therapy unit. Therefore, this review of ped
iatric neurocritical care literature in 1999 highlights central clinical re
ports of the medical management of severe traumatic brain injury, the benzo
diazepines used in the treatment of status epilepticus, and the emerging or
recently appreciated encephalopathies occurring in children. Curr Opin Ped
iatr 2000, 12:222-226 (C) 2000 Lippincott Williams & Wilkins. Inc.