PURPOSE: The aim of this study was to assess the treatment failures of isla
nd-flap anoplasty for fistula-in-ano, a procedure designed to treat fistula
without sphincter division. METHODS: Data concerning all patients having d
ermal island-flap anoplasty for the treatment of transsphincteric fistula w
ere reviewed. Variables assessed were age, gender, radial fistula location,
cause, Crohn's disease, previous fistula operations, other complicating il
lnesses, internal sphincter closure, simultaneous use of fibrin adhesive in
jection, and use of combined dermal and rectal flap for large fistulas. Pos
toperative data collected included persistence of the distal tract, recurre
nce of the fistula, and treatment of the recurrence. Recurrence (or persist
ence) of the fistula was the dependant variable and each risk factor for re
currence was assessed using chi-squared analyses. RESULTS: Seventy-three fl
aps were performed in 65 individuals. Recurrence developed 17 times in 13 i
ndividuals. Recurrence was more likely to occur in males, patients who have
had previous treatment of fistulas, patients with large fistulas requiring
combined flaps, and patients who had simultaneous fibrin glue injection. P
atients with Crohn's disease and individuals having internal sphincter clos
ure had fewer recurrences. Factors reaching statistical significance includ
ed closure of the internal sphincter, the use of fibrin glue, and cause of
the fistula. CONCLUSION: No specific anatomic or demographic characteristic
is sufficiently associated with failure to exclude any patient from the op
eration. Closure of the internal sphincter should be done as part of the pr
ocedure and fibrin glue injection should not be done simultaneously.