Background-Current breath tests for measurement of gastric emptying of soli
ds are expensive, possibly inaccurate, and require cumbersome calculations.
Aims-We wished to validate a simplified solid gastric emptying test using
a [C-13]Spirulina platensis breath test for accurate results relative to sc
intigraphy. Subjects-Thirty healthy volunteers. Methods-We measured gastric
emptying of egg containing [C-13]S platensis and Tc-99m sulphur colloid by
breath (CO2)-C-13 and scintigraphy over six hours. A generalised linear re
gression model was used to predict t(1/2) and t(LAG) by scintigraphy from b
reath (CO2)-C-13 data. The model was cross validated and normative data cal
culated for a prepacked [C-13]meal. Results-Regression models using all bre
ath data over six hours, for the first three hours, and for samples at 75,
90, and 180 minutes ("reduced model") predicted t(1/2) and t(LAG) values si
milar to scintigraphy (t(LAG) 43 (SD 12) min; t(1/2) 100 (20) min). Standar
d deviations of differences in t(1/2) and t(LAG) between scintigraphy and t
he "reduced model" were both 10 minutes. Gastric t(1/2) for the prepacked [
C-13]meal was 91 (15) min (10-90% range: 74-118). Conclusion-The [C-13]S pl
atensis breath test and a simple formula using breath (CO2)-C-13 at baselin
e, 90, and 180 minutes measured gastric emptying t(1/2) for solids with res
ults that were comparable with scintigraphy.