Formal total synthesis of aglaiastatin: Pd(0)-mediated construction of benzofurocyclopentane system

Authors
Watanabe, T Shiraga, Y Takeuchi, T Otsuka, M Umezawa, K
Citation
T. Watanabe et al., Formal total synthesis of aglaiastatin: Pd(0)-mediated construction of benzofurocyclopentane system, HETEROCYCLE, 53(5), 2000, pp. 1051
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
5
Year of publication
2000
Database
ISI
SICI code
0385-5414(20000501)53:5<1051:FTSOAP>2.0.ZU;2-O
Abstract
Aglaiastatin, an antitumor alkaloid, contains fused pentacyclic system, inc luding a benzofurocyclopentane system and a unique pyrrolopyrimidinone skel eton. In this study, synthesis of a keto aldehyde intermediate, a key inter mediate in a previously reported procedure for total synthesis, was accompl ished via Pd(0)-mediated benzofuran ring closure. Thus, a formal total synt hesis of aglaiastatin was achieved.