A novel convenient synthesis of 1,3,5,5-tetrasubstituted hexadydropyrimidine-4-thiones

Authors
Bernat, J Kristian, P Guspanova, J Chomca, I
Citation
J. Bernat et al., A novel convenient synthesis of 1,3,5,5-tetrasubstituted hexadydropyrimidine-4-thiones, HETEROCYCLE, 53(5), 2000, pp. 1171
Citations number
4
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
5
Year of publication
2000
Database
ISI
SICI code
0385-5414(20000501)53:5<1171:ANCSO1>2.0.ZU;2-S
Abstract
Sodium salts of (2-substituted thiocarbamoyl)malonic acid diethyl esters (2 a-d) obtained via reaction of isothiocyanates (1a-d) with sodium diethyl ma lonate afforded with formaldehyde and amine sulfate in water medium diethyl 1,3-disubstituted 4-thioxohexahydropyrimidine-5,5-dicarboxylates (3a-j). R eaction represents the simple and convenient way to synthesize the title co mpounds.