K. Okumura et al., Convenient synthesis of a 2,3,6-tristhiazolyl-substituted pyridine skeleton [fragment A-C] of a macrocyclic antibiotic, GE 2270 A, HETEROCYCLE, 53(4), 2000, pp. 765-770
Convenient synthesis of the 2,3,6-tristhiazolylsubstituted pyridine skeleto
n [Fragment A-C] of a macrocyclic antibiotic, GE 2270 A, was first achieved
from a chiral 2-(2-{2-[(1R,2S)-(1-amino-2-hydroxy-2-phenyl)ethyl]-thiazol-
4-yl}thiazol-4-yl)pyridine derivative [Fragment A] and H-L-Ser-L-Pro-NH2 as
the precursor of Fragment C.