Convenient synthesis of a 2,3,6-tristhiazolyl-substituted pyridine skeleton [fragment A-C] of a macrocyclic antibiotic, GE 2270 A

Citation
K. Okumura et al., Convenient synthesis of a 2,3,6-tristhiazolyl-substituted pyridine skeleton [fragment A-C] of a macrocyclic antibiotic, GE 2270 A, HETEROCYCLE, 53(4), 2000, pp. 765-770
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
4
Year of publication
2000
Pages
765 - 770
Database
ISI
SICI code
0385-5414(20000401)53:4<765:CSOA2P>2.0.ZU;2-7
Abstract
Convenient synthesis of the 2,3,6-tristhiazolylsubstituted pyridine skeleto n [Fragment A-C] of a macrocyclic antibiotic, GE 2270 A, was first achieved from a chiral 2-(2-{2-[(1R,2S)-(1-amino-2-hydroxy-2-phenyl)ethyl]-thiazol- 4-yl}thiazol-4-yl)pyridine derivative [Fragment A] and H-L-Ser-L-Pro-NH2 as the precursor of Fragment C.