Interaction of human phagocytes with pigmentless Aspergillus conidia

Authors
Jahn, B Boukhallouk, F Lotz, J Langfelder, K Wanner, G Brakhage, AA
Citation
B. Jahn et al., Interaction of human phagocytes with pigmentless Aspergillus conidia, INFEC IMMUN, 68(6), 2000, pp. 3736-3739
Citations number
19
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
6
Year of publication
2000
Pages
3736 - 3739
Database
ISI
SICI code
0019-9567(200006)68:6<3736:IOHPWP>2.0.ZU;2-R
Abstract
A defect in the pksP gene of Aspergillus fumigatus is associated with the l oss of conidial pigmentation, a profound change of the conidial surface str ucture, and reduced virulence. The structural change of the conidial surfac e structure was not observed in similar A. nidulans wA mutants. Our data in dicate that the pigment of both species is important for scavenging reactiv e oxygen species and for protection of conidia against oxidative damage.