High prevalence of resistance to clindamycin in Bacteroides fragilis groupisolates

Susceptibility to anti-anaerobic agents in the Bacteroides fragilis group v aries according to the geographical region studied. In recent years there h as been a reduction in the susceptibility of such isolates, particularly to antibiotics such as clindamycin and cefoxitin. The antimicrobial susceptib ilities of 100 isolates of the B. fragilis group isolated in 1998 from faec al samples of healthy people to clindamycin and five other anti-anaerobic a gents were determined. Meropenem, metronidazole and trovafloxacin showed ex cellent activity against all isolates. The efficacy of cefoxitin was low, w ith only 46% of isolates susceptible. A high prevalence of resistance to cl indamycin (49% of isolates) was observed.