Effect of cyclodextrins on small intestinal mucosa and glucose absorption in the rat

Cyclodextrin (CD) is the cyclic oligomer of glucose and can uptake hydropho bic molecules irt its structure, In the present study, the influences of th ree hinds of CD on rat intestinal mucosa and absorptional function of gluco se were studied. This investigation was done by perfusing the solutions int o rat small intestine. beta-CD and gamma-CD, not alpha-CD, extracted choles terol from small intestinal mucosa. Three CDs did not extract phospholipids and protein, the other components of cell membrane, from small intestinal mucosa. These results suggested that decrease Of glucose absorption via act ive transport system by beta-CD is due to the interaction between the membr ane components and beta-CD. This interaction would induce changes of membra ne structure, resulting in inhibition of the route of glucose absorption vi a Na+-glucose co-transporter.