Reactivity of omega-hydroxyalkylphosphinic anilides in cyclisation by intramolecular displacement of the aniline moiety

Authors
Collison, S Harger, MJP
Citation
S. Collison et Mjp. Harger, Reactivity of omega-hydroxyalkylphosphinic anilides in cyclisation by intramolecular displacement of the aniline moiety, J CHEM R-S, (1), 2000, pp. 28-29
Citations number
7
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
1
Year of publication
2000
Pages
28 - 29
Database
ISI
SICI code
0308-2342(200001):1<28:ROOAIC>2.0.ZU;2-M
Abstract
A cyclic phosphinate 2 is formed when HO(CH2)(n+3)P(O)(NHPh)Ph (n = 0 or 1) is treated with acid (P-N bond cleavage); five-membered ring formation (n = 0) is 70 times faster than six in CHCl3 and 50 times faster in MeOH.