Background: In recent years, the management of acute myocardial infarction
(AMI) has been the subject of many clinical trials. These studies have clea
rly established the value of using pharmacological agents, including aspiri
n, beta-blockers, thrombolytics and angiotensin converting enzyme (ACE) inh
ibitors. There have been suggestions, however, that practice has been slow
to change in light of the findings of these trials.
Aim: To review cases of AMI at the major teaching hospital in Tasmania, Aus
tralia, to determine whether the recommendations from the results of the tr
ials had been translated into local clinical practice, and to examine tempo
ral changes in drug usage and clinical outcomes.
Methods: A retrospective review of the medical records of patients admitted
to the hospital with an AMI during 1996 and for the first four months of 1
998 was performed. An extensive range of demographic and clinical variables
was recorded, and differences between the 1996 and 1998 patients and betwe
en recipients and non-recipients of the different pharmacological agents we
re statistically evaluated.
Results: The patients had a mean age of 65.9 +/- 12.3 years in 1996 (n = 20
5) and 66.8 +/- 12.3 years in 1998 (n = 71), with males accounting for 64.4
% of cases in 1996 and 64.8% of cases in 1998. There were no significant de
mographic or medical history differences between the two groups. The median
time of presentation after the onset of chest pain was 3.5 h in 1996 and 4
h in 1998. The rates of use of major therapeutic interventions post-AMI fo
r 1996 and 1998, respectively, were: aspirin (89.1%, 90.3%), streptokinase
(18.5%, 9.9%), r-tPA (14.1%, 21.1%), intravenous beta-blockers (11.2%, 7.0%
), oral beta-blockers (67.2%, 49.3%; P < 0.01), ACE inhibitors (44.4%, 59.2
%; P < 0.05), intravenous nitrate (94.1%, 91.6%), oral nitrate (22.9%, 26.8
%), calcium channel antagonists (19.5%, 35.2%; P < 0.05), cholesterol lower
ing agents (26.3%, 40.9%; P < 0.05), antiarrhythmics (21.5%, 25.4%) and war
farin (8.3%, 9.9%). Patients who received therapy with each of aspirin, r-t
PA, intravenous beta-blockers, oral beta-blockers, intravenous nitrate and
cholesterol lowering agents were significantly younger than the non-recipie
nts (all P < 0.01), while patients treated with ACE inhibitors and antiarrh
ythmics were significantly older than the non-recipients (both P < 0.001).
Non-recipients of thrombolytics presented to hospital significantly later,
on average, than recipients. The hospital mortality rate was 15.1% in 1996
and 12.7% in 1998, and adverse drug reactions occurred in 21.5% of patients
in 1996 and 15.5% in 1998.
Conclusions: Although there have been substantial increases in the use of A
CE inhibitors and cholesterol lowering agents post-AMI in recent years, red
uctions in the use of thrombolytics and beta-blockers and their possible un
deruse in the elderly are of concern and warrant intervention.