Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 17. Preparation of 1H-thieno[2,3-b][1,4]thiazine-1-carboxamides as smooth muscle relaxants
Me. Schreder et T. Erker, Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 17. Preparation of 1H-thieno[2,3-b][1,4]thiazine-1-carboxamides as smooth muscle relaxants, J HETERO CH, 37(2), 2000, pp. 349-354
A new series of substituted thieno[1,4]thiazines with an urea moiety has be
en designed. The synthesis and results of replacement of the quinoline and
indoline moieties of lead structure 1 are described. The key step in prepar
ation was the substitution with 4-nitrophenyl chloroformate to obtain the r
equired reactivity for substitution with diamines. Structural modifications
of the amino side chain with the aim of finding tissue specific compounds
were carried out. Pharmacological testings explored the presumed calcium-ch
annel-antagonistic and potassium-channel-opening activities.