Synthesis of new thieno and pyrazolo[2,1]benzothiazepine derivatives with potential antidepressant properties

Authors
Vega, S Diaz, JA Darias, V Mateo, CCS
Citation
S. Vega et al., Synthesis of new thieno and pyrazolo[2,1]benzothiazepine derivatives with potential antidepressant properties, J HETERO CH, 37(2), 2000, pp. 389-393
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
37
Issue
2
Year of publication
2000
Pages
389 - 393
Database
ISI
SICI code
0022-152X(200003/04)37:2<389:SONTAP>2.0.ZU;2-H
Abstract
In this paper we describe a series of new thieno and pyrazolo[2,1]benzothia zepine derivatives 7a-o which were synthesized by two different methods bot h starting from the previously described tricyclic alcohols 1-3. Several co mponents of this series were effective p.o. (per os, orally) in different p harmacological tests currently employed in the evaluation of antidepressant activity.