Reaction of 4,5,6-triaminopyrimidine and 2,4,5,6-tetraaminopyrimidine with3-dimethylaminopropiophenones. Synthesis of new 4-aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines

Authors
Insuasty, B Insuasty, H Quiroga, J Saitz, C Jullian, C
Citation
B. Insuasty et al., Reaction of 4,5,6-triaminopyrimidine and 2,4,5,6-tetraaminopyrimidine with3-dimethylaminopropiophenones. Synthesis of new 4-aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines, J HETERO CH, 37(2), 2000, pp. 401-403
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
37
Issue
2
Year of publication
2000
Pages
401 - 403
Database
ISI
SICI code
0022-152X(200003/04)37:2<401:RO4A2W>2.0.ZU;2-1
Abstract
Several new 6-amino- and 6,8-dinmino-4-aryl-2,3-dihydropyrimido[4,5-b][1,4] diazepines were obtained from the reaction of 4,5,6-triaminopyrimidine 1a a nd 2,4,5,6-tetraaminopyrimidine 1b with one equivalent of 3-dimethylaminopr opiophenones 2 in absolute ethanol. Structure analysis of 6-amino- and 6,8- diamino-4-aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines 3a-i, determined b y detailed nmr measurements, reveals a high regioselectivity of this reacti on.