A heat-transfer analysis was performed on thermocapillary pumping, a surfac
e-tension-based drop pumping mechanism. The analysis, which incorporates bo
th fluid flow and energy transport through multiple device layers, reveals
effective material, design, and operational choices that result in improved
pumping performance. Important design factors include thermal conductivity
, channel/substrate thickness, and the velocity of the liquid drops. Result
s for pumping a drop of water on a fused silica substrate with a glass chan
nel show that uniform interface temperatures can be achieved with bottom he
ating as lung as drop velocities remain below similar to 0.1 cm s(-1). The
analysis was also extended to include thermal reaction channels. The reacto
r analysis verified that relatively uniform reaction temperatures were atta
inable with bottom heating as long as channel heights were below similar to
100 mu m.