New 7,20 : 14,20-diepoxy ent-kauranoids from Isodon xerophilus

Authors
Hou, AJ Li, ML Jiang, B Lin, ZW Ji, SY Zhou, YP Sun, HD
Citation
Aj. Hou et al., New 7,20 : 14,20-diepoxy ent-kauranoids from Isodon xerophilus, J NAT PROD, 63(5), 2000, pp. 599-601
Citations number
12
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
5
Year of publication
2000
Pages
599 - 601
Database
ISI
SICI code
0163-3864(200005)63:5<599:N7:1EF>2.0.ZU;2-4
Abstract
Three new 7,20:14,20-diepoxy-ent-kaurane diterpenoids, xerophilusins A-C (1 -3), together with a known one, macrocalin B (4), were isolated from the le aves of Isodon. xerophilus. Their structures were elucidated on the basis o f their spectral properties and X-ray crystallographic analysis. Compounds 1, 2, and 4 showed significant cytotoxic activity against K562, HL-60, and MKN-28 cells.