Nm. Carballeira et M. Pagan, Identification and total synthesis of a novel dimethylated fatty acid fromthe Caribbean sponge Calyx podatypa, J NAT PROD, 63(5), 2000, pp. 666-669
The dimethylated fatty acid 9,13-dimethyltetradecanoic acid was identified
for the first time in nature in the Caribbean sponge Calyx podatypa where i
t occurs together with the rare 10,13-dimethyltetradecanoic acid. The chara
cterization of the novel compound was accomplished using GC-MS, pyrrolidide
derivatization, and a five-step total synthesis starting with 8-bromooctan
oic acid. The first racemic total synthesis for the rare 10,13-dimethyltetr
adecanoic acid is also described.